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This combination medication is employed to treat signs of Parkinson's disease or Parkinson-like symptoms (such as shakiness, stiffness, difficulty moving). Parkinson's disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the mind. Levodopa modifications into dopamine in the brain, assisting to control movement. Carbidopa stops the breakdown of levodopa in the bloodstream so more levodopa can enter mental performance. Carbidopa can additionally reduce some of levodopa's side effects such as vomiting and nausea.

How to use Sinemet

Take this medication by mouth with or without food as directed by your doctor, often 3 to 4 times each day.

Using this medication with meals might help to decrease nausea. It is best to avoid a diet that is high-proteinit decreases the level of levodopa that your body takes in) during therapy, unless directed otherwise by your doctor. Separate your dosage with this medication by since hours that are many possible from any iron supplements or products containing iron (such as multivitamins with minerals) you may take. Iron can reduce the amount of this medication absorbed by the body. Consult your pharmacist or doctor for more details.

The dosage is situated on your condition that is medical and to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your physician's directions carefully. This combination medication comes in different strengths with different amounts of levodopa and carbidopa in each tablet. Be sure you have the strength that is correct of drugs. Your doctor may also alone prescribe carbidopa to be used with this combination.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Some patients may experience a "wearing-off" (worsening of symptoms) before the next dose is due. An "on-off" impact may additionally happen, in which unexpected short periods of stiffness occur. If these effects occur, contact your physician for feasible dosage adjustments which will help to minimize this effect.

Do not stop taking this medication without consulting your physician. Some conditions can become even worse whenever this drug is quickly reduced or suddenly stopped. Your dose may gradually need to be reduced. (See also negative effects section.)

Tell your physician when your condition will not improve or if it worsens.

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Side Results

Dizziness, lightheadedness, nausea, vomiting, loss of appetite, difficulty sleeping, unusual dreams, or headache may occur. If some of these effects persist or worsen, tell your pharmacist or doctor immediately.

This medication may cause saliva, urine, or perspiration to turn a color that is dark. This effect is harmless, but your clothes might be stained.

To lessen the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of adverse effects. Many people using this medication do not have adverse that is serious.

Some people taking this medication have dropped asleep unexpectedly in their usual activities that are dailysuch as talking on the phone, driving). In some full cases, sleep occurred without any emotions of drowsiness ahead of time. This sleep impact may occur anytime during therapy with carbidopa/levodopa regardless if you used this medication for a long time. If you experience increased sleepiness or fall asleep during the day, do not drive or do other possibly dangerous activities until you have discussed this effect with your doctor. Your danger of the sleep effect is increased by utilizing liquor or other medicines that will cause you to drowsy. See also Precautions section.

Tell your doctor immediately if you have any serious adverse effects, including: new/worsening movements you can't control/spasms, greatly increased eye blinking/twitching, fainting, vision changes (such as blurred vision, double vision), eye pain, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds, mental/mood changes (such as agitation, hallucinations, depression, thoughts of suicide), signs of infection (such as sore throat that doesn't go away), easy bleeding/bruising, unusual tiredness, tingling of the hands/feet, unusual strong urges (such as increased gambling, increased sexual urges).

Get help that is medical away if you have any very severe adverse impacts, including: upper body pain.

Suddenly stopping or reducing the dose with this medication may rarely cause a tremendously serious condition called neuroleptic malignant syndrome (NMS). Get medical help immediately when you yourself have any of the after symptoms: fever, uncommon muscle mass stiffness, severe confusion, sweating, fast/irregular heartbeat, quick breathing.

a very serious allergic reaction to this drug is rare. However, get help that is medical away in the event that you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially associated with the face/tongue/throat), severe dizziness, difficulty respiration.

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This is maybe not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the usa -

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Call your physician for medical advice about side-effects. You'll report adverse effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your medical practitioner for medical advice about side results. You may report adverse effects to Health Canada at 1-866-234-2345.


Before using this medication, tell your doctor or pharmacist if you are allergic to carbidopa or levodopa; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergy symptoms or other problems. Speak to your pharmacist for lots more details.

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Before by using this medicine, tell your doctor or pharmacist your medical background, especially of: liver disease, glaucoma, respiration issues (such as for instance asthma), heart disease (such as for instance coronary arrest, irregular heartbeat), kidney illness, stomach/intestinal ulcer, mental/mood disorders (such as depression, schizophrenia), blood problems, seizures, rest disorders.

This drug might make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness you can perform such activities safely until you are sure. Limit beverages that are alcoholic. See also Side Results section.

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Before having surgery, tell your doctor or dentist about most of the products you use (including prescription drugs, nonprescription drugs, and natural products).

During pregnancy, this medication should be utilized only once plainly needed. Discuss the risks and benefits with your physician.

Levodopa passes into breast milk. It is unknown if carbidopa passes into breast milk. Consult your doctor before breast-feeding.

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