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Baclofen can be used for treating spasm of skeletal muscles that create muscle clonus, rigidity, and pain as a result of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also referred to as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to communicate collectively. GABA released by some nerves causes the adventure of other nerves to diminish. It is belief that Baclofen, acting like GABA, blocks the game of nerves within the area of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
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The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose might be increased gradually every 3 days to some maximum of 80 mg/day in several doses.
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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of your reach of kids.
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Baclofen could potentially cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
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Abrupt discontinuation of oral Baclofen might cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
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Use of Baclofen to drugs this depress the function of nerves can lead to additional reduction in brain function.
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In addition to the probability of depressing brain function, the use of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together may cause muscle weakness.
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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) may result in greater depression of brain function in addition to low blood pressure.
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As Baclofen can increase blood glucose, doses of antidiabetic drugs might need to be adjusted when Baclofen is taken.
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The use of Baclofen by pregnant women has not been evaluated.
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Baclofen could be detected within the breast milk of mothers taking oral Baclofen. No facts are available on a good Baclofen in the breast milk of mothers receiving Baclofen intrathecally.
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