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Baclofen is employed for treating spasm of skeletal muscles that induce muscle clonus, rigidity, and pain on account of multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter inside brain. Neurotransmitters are chemicals that nerves use to talk collectively. GABA released by some nerves causes the experience of other nerves to diminish. It is considered that Baclofen, acting like GABA, blocks the activity of nerves within the section of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was licensed by the FDA in November, 1977.
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The usual starting dose of Baclofen for adults is 5 mg thrice daily. Based on the response, the dose could be increased gradually every three days to your maximum of 80 mg/day in many doses.
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Baclofen ought to be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of children.
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Baclofen could cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low hypertension, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
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Abrupt discontinuation of oral Baclofen could potentially cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).
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Use of Baclofen with other drugs that also depress the function of nerves may result in additional reduction in brain function.
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In addition to the risk of depressing brain function, the usage of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together may cause muscle weakness.
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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can result in greater depression of brain function in addition to low blood pressure level.
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As Baclofen can increase blood glucose, doses of antidiabetic drugs may need to be adjusted when Baclofen is taken.
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The using Baclofen by expecting mothers hasn't been evaluated.
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Baclofen might be detected within the breast milk of mothers taking oral Baclofen. No facts are entirely on the use of Baclofen within the breast milk of mothers receiving Baclofen intrathecally.
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