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NOOTROPIL is indicated for patients experiencing myoclonus of cortical origin, irrespective of aetiology, and will supply in conjunction with other anti-myoclonic therapies.

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The dosage regime shows important interindividual variability, requiring an individualised dose finding approach. A reasonable protocol is usually to introduce piracetam in a dosage of 7.2 g/day, increasing by 4.8 g/day every three or four days up to maximum of 20g/day, given in either two or three divided doses whilst keeping other antimyoclonic drugs unchanged at their optimal dosage. If possible, determined by clinical benefit, a shot must be made to subsequently slow up the dosage of other antimyoclonic drugs.

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Side Effects

The unwanted effects reported in association with Nootropil include nervousness, agitation, irritability, anxiety and sleep disturbances. The incidence of such during clinical trials was 5% or less and they also were more frequently noted within the older patients taking a lot more than 2.4 g daily. In the majority of cases a dose reduction sufficed to create these symptoms disappeared. Some patients may complain of fatigue or drowsiness. Gastro-intestinal problems including nausea, vomiting, diarrhoea and stomachache have been reported, on the other hand Incidence during clinical trials was 2% or less. Other symptoms, for example vertigo, headaches, trembling and sexual stimulation have occasionally been reported.

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NOOTROPIL (Piracetam) is contra-indicated in patients with severe renal impairment (renal creatinine clearance of below 20 ml each and every minute), hepatic impairment and those under 16 years old. It is also contraindicated in patients with cerebral haemorrhage, Huntington's Chorea and in those that have hypersensitivity to piracetam, other pyrrolidone derivatives or the excipients .

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