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ARAVA is indicated in adults to the treating active rheumatism (RA):

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Take this medicine only as directed by your doctor. Do not take really it, do not take on it more regularly, and do not take it a bit longer than your medical professional ordered.

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The dose with this medicine vary many different patients. Follow your medical professional's orders or directions about the label. The following information includes exactly the average doses of this medicine. If your dose is different, don't put it back unless your doctor notifys you to do so.

The volume of medicine that you simply take depends on the strength from the medicine. Also, the quantity of doses you take every day, the time allowed between doses, and also the period of time you are taking the medicine depend for the medical problem that you can are employing the medicine.

For oral dosage form (tablets):

For rheumatism:

If you miss a dose with this medicine, go as soon as possible. However, if it is almost time for your forthcoming dose, skip the missed dose and get back on your family dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions able to 15-30°C (59-86°F). Protect from light. Keep out from the reach of children. Do not keep outdated medicine or medicine will no longer needed. Store the medicine in a closed container at room temperature, away from heat, moisture.

 Keep out of the reach of children. Do not keep outdated medicine or medicine no more needed. Store the medicine in a very closed container at room temperature, from heat, moisture.


Side Effects

Stop by using this medicine and appearance with your medical professional straight away if you're having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions from the utilization of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along using its needed effects, medicines could cause some unwanted effects. Although not most of these negative effects may occur, if they do occur they will often need medical help.

Check with your doctor immediately if any of the following side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
decrease of appetite
nausea / vomiting
sore throat
tightness inside chest
yellow eyes or skin
Less common
Burning feeling within the chest or stomach
burning, prickling, or tingling sensation inside fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
lack of breath
tenderness inside stomach area
unusual tiredness or weakness
Incidence unfamiliar
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening from the skin
blood within the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general feeling of tiredness or weakness
high fever
large, hive-like swelling around the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
lower back or side pain
pains inside stomach, side, or abdomen, possibly radiating for the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red wounds, often with a purple center
red, irritated eyes
sores, ulcers, or white spots within the mouth or for the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness inside the arms, hands, legs, or feet

Some unwanted side effects may occur very often do not need medical help. These unwanted side effects might have to go away during treatment as your body adjusts on the medicine. Also, your wellbeing care professional could possibly inform you of ways to prevent or reduce a few of these unwanted effects. Check using your health care professional if any with the following side effects continue or are bothersome or if you have questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness with the mouth
itching in the skin
pain or burning in the throat
runny nose

Other side effects not listed can also appear in some patients. If you notice some other effects, check together with your healthcare professional.



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It is critical that a medical expert look at the progress at regular visits to make certain that this prescription medication is functional. Blood tests are usually necesary to evaluate for unwanted side effects.

Using this medicine while you are pregnant can harm your child. Use an effective type of birth control to maintain from having a baby. If you think you have get pregnant while using the medicine, tell a medical expert immediately.

Leflunomide can also cause birth defects if your father is applying it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a way of birth control method during sex. A man aiming to father a child should stop using this medicine and look along with his doctor without delay.

Serious skin reactions can happen using this type of medicine. Stop employing this medicine and look with a medical expert straight away if you might have any in the following symptoms while investing in this medicine: blistering, peeling, or loosening of the skin; chills; itching; joint or muscle pain; red wounds, often which has a purple center; sores, ulcers, or white spots within the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are utilizing this medicine. Stop applying this medicine and appearance with your medical professional straight away in case you are having multiple of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; decrease of appetite; queasiness; skin rash; swelling of the feet or calves; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells in your blood, improving the chance of getting disease. It can also lower the number of platelets, which are required for proper blood clotting. If this occurs, there are particular precautions you'll be able to take, particularly if your blood count is low, to lessen potential risk of infection or bleeding:

Check with your medical professional straight away if you have a cough with or without nausea, shortness of breath, or any issue with breathing.

You will need to have a skin test for tuberculosis before you begin employing this medicine. Tell your medical professional if you or anyone in your home has ever had a good response to a tuberculosis test.

Using this medicine may enhance your risk of getting serious infections or cancer. Talk to a medical expert if you have concerns relating to this risk.

Do not take other medicines unless they've been discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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