Tamoxifen is used for treating cancer of the breast which includes spread to other sites in the body. It is also used along with other medicines to treat other types of cancer of the breast. It is used in women who are at high risk for breast cancers plus women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancers. Tamoxifen is definitely an antiestrogen. It works by blocking the effects of estrogen on certain tumors. This may stop the development of tumors which might be activated by estrogen.
INSTRUCTIONS
Use Tamoxifen as directed through your doctor.
Tamoxifen could be taken by mouth with or without food.
Take Tamoxifen with water and other nonalcoholic liquid.
Swallow prescription drugs whole. Do not break, crush, or chew before swallowing.
Continue to consider Tamoxifen even though you feel well. Do not miss any dose. Taking Tamoxifen as well daily will aid you to remember to look at it.
If you miss a dose of Tamoxifen, go on it as soon as possible. If it is almost time for your upcoming dose, skip the missed dose and go back to your normal dosing schedule. Do not take 2 doses simultaneously.
Ask your medical provider questions you might have regarding how to use Tamoxifen.
STORAGE
Store Tamoxifen between 68 and 77 degrees F (20 and 25 degrees C) in a very tightly closed, light-resistant container. Store away from moisture, heat, and light-weight. Do not store inside bathroom. Do not take tablets as soon as the expiration date printed on the label. Keep Tamoxifen out of your reach of children and far from pets.
Side Effects
All medicines could cause unwanted side effects, but a majority of folks have no, or minor, unwanted side effects.
Check along with your doctor if these most common unwanted effects persist or become bothersome:
Bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; fat loss.
Seek medical assistance straight away if these severe negative effects occur:
Severe allergies (rash; hives; itching; breathlessness; tightness inside the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; paying blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; decrease of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in a single or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; breathlessness; skin changes; stomach pain; sudden severe headache; swelling in the arms or even the legs; unusual bleeding or bruising; vision or speech problems; yellowing in the eyes or skin.
This is not a complete set of all side effects that will occur. If you have questions regarding negative effects, contact your doctor.
Precautions
Do NOT use Tamoxifen if:
you are allergic to the ingredient in Tamoxifen
you are using Tamoxifen to reduce your chance of breast cancer and you have past blood clots within the lung or leg
you are employing Tamoxifen to cut back your probability of breast cancer so you take certain anticoagulants (eg, warfarin)
you are taking anastrozole.
Contact a medical expert or doctor right away if some of these apply to you.
Some medical ailments may communicate with Tamoxifen. Tell a medical expert or pharmacist if you have any health conditions, particularly if any of the following apply to you:
if you happen to be pregnant, about to conceive, or are breast-feeding
if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
in case you have allergies to medicines, foods, or another substances
for those who have a history of blood clots in the legs or lungs
if you have high numbers of calcium with your blood, a weakened immune system, or low numbers of white blood cells or platelets in your blood
if you have high cholesterol or lipid levels
for those who have cataracts or another vision problems
if you are choosing cytotoxic cancer medicines
if you're confined to a bed or chair.
Some medicines may interact with Tamoxifen. Tell your health care provider if you consider any other medicines, especially any of the following:
Anticoagulants (eg, warfarin) because the potential risk of bleeding could be increased
Cytotoxic cancer medicines (eg, cisplatin) because the risk of developing blood clots could possibly be increased
Rifampin given it may decrease Tamoxifen's effectiveness
Fluorouracil or mitomycin C because they may increase potential risk of Tamoxifen's unwanted effects
Aromatase inhibitors (eg, anastrozole, letrozole) as their effectiveness may be decreased by Tamoxifen.
This will not be a complete set of all interactions that may occur. Ask your health care provider if Tamoxifen may talk with other medicines that you simply take. Check with your medical provider before starting, stop, or change the dose from a medicine.
Important safety information:
Tamoxifen might cause dizziness. These effects could be worse if you get it with alcohol or certain medicines. Use Tamoxifen with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you react to it.
Tamoxifen may slow up the variety of clot-forming cells (platelets) inside your blood. Avoid activities that could cause bruising or injury. Tell your doctor when you have unusual bruising or bleeding. Tell your medical professional when you have dark, tarry, or bloody stools.
Tamoxifen may lower the ability of the body to fight infection. Avoid connection with folks who suffer from colds or infections. Tell your medical professional if you notice signs and symptoms of infection like fever, sore throat, rash, or chills.
New tumors have took place body sites aside from the uterus in patients taking Tamoxifen. It is unknown if Tamoxifen might be the cause. Discuss any queries or concerns with your doctor.
Women having Tamoxifen to reduce the chance of breast cancers needs to have a breast exam, mammogram, and gynecological exam before starting and during treatment with Tamoxifen.
Women who may become pregnant must start taking Tamoxifen during a monthly period. Women who have irregular menstrual periods should have a pregnancy test immediately before commencing Tamoxifen. Talk to your doctor in case you have any questions regarding how to begin taking Tamoxifen.
Women who may get pregnant must use effective nonhormonal contraceptive (eg, condoms, diaphragm) during intercourse while they consider Tamoxifen as well as for 8 weeks as soon as they stop taking it. Do not use hormonal birth control method (eg, contraception pills); it may not work as well as you are taking Tamoxifen. Discuss questions about effective nonhormonal contraception together with your doctor.
Tamoxifen is not going to stop you from getting pregnant.
Lab tests, including breast exams, mammograms, gynecologic exams, complete blood counts, and liver function tests, might be performed as you use Tamoxifen. These tests could be used to monitor your condition or search for side effects. Be sure to keep all doctor and lab appointments.
Tamoxifen needs to be used in combination with warning in youngsters; safety and effectiveness in kids weren't confirmed.
Pregnancy and breast-feeding: Tamoxifen could potentially cause injury to the fetus. Do not become pregnant while you are choosing it and for 2 months once you stop deploying it. If you think you could be pregnant, get hold of your doctor. You will need to discuss the advantages and perils associated with using Tamoxifen while you are pregnant. It is not known if Tamoxifen is located in breast milk. Do not breastfeed while taking Tamoxifen.
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