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Uses

INDICATIONS

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Indinavir is definitely an antiviral medication in a number of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Indinavir isn't a cure for HIV or AIDS.

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INSTRUCTIONS

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Take indinavir the same manner it was prescribed in your case. Do not make medication in larger amounts, or take it for more than recommended by your doctor. Follow the directions on your prescription label.

This medication is sold with patient instructions for secure and efficient use. Follow these directions carefully. Ask a medical expert or pharmacist if you have any queries.
Take indinavir with a full glass (8 ounces) of water or skim milk. You can also drink juice, coffee, or tea with this medication. Drink at the very least 6 associated with water daily to stop kidney stones when you are taking indinavir. Indinavir ought to be taken on jail stomach, no less than an hour before or a couple of hours from a meal.

If you prefer to consider the medication with food, eat simply a light meal, including dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is very important to utilize indinavir regularly to find the most benefit. Get your prescription refilled before you run out of drugs completely.

To make sure medicines is assisting your complaint, your blood must be tested on a regular basis. Your liver function might also should be tested. Do not miss any scheduled visits to a medical expert.

HIV/AIDS is normally treated with a combination of different drugs. To best treat your problem, utilize all of the medications as directed by your doctor. Be sure to see the medication guide or patient instructions given each of the medications. Do not make positive changes to doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain beneath the proper care of a physician.

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Take the missed dose as soon as you remember and take your following dose at the regularly scheduled time. If you are more than couple of hours late in taking your indinavir, skip the missed dose and consider the next regularly scheduled dose. Do not take extra medicine to generate up the missed dose.

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DOSAGE

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Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis ought to be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is probably the alternative regimens appropriate for nonoccupational postexposure HIV prophylaxis.

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Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to 120 minutes postexposure. The exact duration of therapy may differ in line with the institution's protocol.

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Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider decreasing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence to the prescribed dose is crucial. Patients shouldn't alter the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is essential during therapy to lessen the risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation may be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

Store indinavir at room temperature away from moisture and heat. Keep the capsules in their original container, along with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

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Side Effects

Get emergency medical help if you have some of these signs of a hypersensitive reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking indinavir and call your doctor immediately for those who have all of these serious unwanted side effects:

Less serious negative effects can include:

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This isn't a complete listing of unwanted side effects and others may occur. Tell your physician about any unusual or bothersome side effect.

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Precautions

Do not take medicines in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines for example ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs may cause life-threatening unwanted side effects if you utilize them while you are taking indinavir.

Before taking indinavir, tell your medical professional if you are allergic to any drugs, or when you have:

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If you've all of these conditions, you need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication might be unhealthy for an child. Tell a medical expert should you be pregnant or want to get pregnant during treatment. HIV might be passed for the baby if your mother just isn't properly treated when pregnant. Take all of your respective HIV medicines as given to take control of your infection when you are pregnant.

Your name may must be listed on an antiviral pregnancy registry when you start using this medication.
You should not breast-feed if you are using indinavir. Women with HIV or AIDS ought not breast-feed at all. Even if your infant arrives without HIV, you may still pass the herpes simplex virus on the baby inside your breast milk.

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