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Uses

INDICATIONS

Indinavir is definitely an antiviral medication in a very group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is used to treat HIV, which in turn causes acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

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INSTRUCTIONS

Take indinavir exactly as it had been prescribed for you. Do not go ahead and take medication in larger amounts, or get it for more than recommended by your doctor. Follow the directions on your prescription label.

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This medication includes patient instructions for safe and effective use. Follow these directions carefully. Ask a medical expert or pharmacist for those who have any questions.

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Take indinavir which has a full glass (8 ounces) of water or skim milk. You could also drink juice, coffee, or tea using this medication. Drink at least 6 associated with water daily to avoid kidney stones while you are taking indinavir. Indinavir ought to be taken on an empty stomach, no less than 1 hour before or 2 hours following a meal.

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If you prefer to make medication with food, eat only a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

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It is very important to make use of indinavir regularly to have the most benefit. Get your prescription refilled before you run out of drugs completely.

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To be sure this medication is assisting your condition, your blood must be tested frequently. Your liver function may also have to be tested. Do not miss any scheduled visits to your physician.

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HIV/AIDS is normally treated using a combination of different drugs. To best treat your problem, utilise all of your medications as directed because of your doctor. Be sure to read the medication guide or patient instructions supplied with each of one's medications. Do not change your doses or medication schedule without advice from a medical expert. Every person with HIV or AIDS should remain within the proper care of a physician.

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Take the missed dose once you remember and take the following dose in the regularly scheduled time. If you are over a couple of hours late in taking your indinavir, skip the missed dose and go ahead and take next regularly scheduled dose. Do not take extra medicine to make in the missed dose.

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DOSAGE

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Usual Adult Dose for HIV Infection

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800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.

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800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis must be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.

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Indinavir plus ritonavir plus 2 NRTIs is among the alternative regimens recommended for nonoccupational postexposure HIV prophylaxis.

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800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,

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or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.

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Duration: Therapy must start promptly, preferably within 1 to 2 hours postexposure. The exact use of therapy could differ depending on the institution's protocol.

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Liver Dose Adjustments

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Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.

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Dose Adjustments

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Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.

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Precautions

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Strict adherence for the prescribed dose is essential. Patients shouldn't modify the dose or discontinue therapy without conferring with their physician.

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Adequate hydration (1.5 liters/day) is crucial during therapy to lessen potential risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could be necessary if nephrolithiasis occurs.

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Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

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STORAGE

Store indinavir at room temperature faraway from moisture as well as heat. Keep the capsules of their original container, with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

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Side Effects

Get emergency medical help in case you have some of these signs of an allergic reaction: hives; lack of breath; swelling of one's face, lips, tongue, or throat. Stop taking indinavir and call a medical expert at the same time for those who have some of these serious unwanted side effects:

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Less serious unwanted side effects may include:

This is just not a complete set of negative effects yet others may occur. Tell your medical professional about any unusual or bothersome side-effect.

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Precautions

Do not take medicines if you're allergic to indinavir.

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Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines for example ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs could cause life-threatening unwanted side effects the use of them while you are taking indinavir.

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Before taking indinavir, tell your medical professional if you are allergic to any drugs, or in case you have:

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If you have any of these conditions, you might need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could possibly be harmful to an child. Tell your doctor if you are pregnant or prefer to get pregnant during treatment. HIV may be passed on the baby if the mother is just not properly treated in pregnancy. Take all of the HIV medicines as given to overcome your infection while you are pregnant.

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Your name may must be from an antiviral pregnancy registry when you begin using medicines.
You shouldn't breast-feed if you are using indinavir. Women with HIV or AIDS ought not breast-feed whatsoever. Even if your child comes into the world without HIV, you might still pass herpes towards the baby within your breast milk.

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