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Do NOT use Clozaril if:

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• you've uncontrolled seizures (eg, epilepsy) or loss in bowel muscle movement (paralytic ileus)

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• you take other medicines that could potentially cause blood problems. Ask a medical expert in case you are unsure if any of your medicines may cause blood problems.

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Contact a medical expert or physician right away if some of these connect with you.

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Some health conditions may interact with Clozaril. Tell a medical expert or pharmacist if you have any health conditions, especially if any from the following apply to you:

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• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement

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• when you have a history of the enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel obstruction; or dementia

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Some medicines may interact with Clozaril. Tell your doctor if you take another medicines, especially any of the following:

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• Benzodiazepines (eg, lorazepam) or another medicines for mental or mood problems since the risk of heart or breathing problems might be increased

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• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they might increase the probability of Clozaril's negative effects

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• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin since they may decrease Clozaril's effectiveness

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• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) for the reason that likelihood of their negative effects might be increased by Clozaril.

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This will not be a total list of all interactions that will occur. Ask your doctor if Clozaril may connect to other medicines which you take. Check together with your physician before you begin, stop, or customize the dose from a medicine.

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Important safety information:

• Clozaril could potentially cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you go with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks until you understand how you react to it.

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• Do not use alcohol or medicines that might cause drowsiness (eg, sleep aids, muscle relaxers) whilst you taking Clozaril. It may grow their effects. Ask the pharmacist in case you have questions on which medicines may cause drowsiness.

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• Clozaril could cause dizziness, lightheadedness, or fainting; alcohol, summer, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially inside the morning. Sit or take a nap at the first manifestation of some of these effects.

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• Clozaril may lower the ability of your system to battle infection. Avoid contact with folks who suffer from colds or infections. Tell your doctor without delay if you see any indications of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.

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• Women and patients of Jewish background might be at greater likelihood of developing blood difficulties with Clozaril.

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• If you've a history of seizures, you could possibly suddenly lose conscious as you are taking Clozaril. Avoid activities by which decrease of conscious could possibly be dangerous for your requirements varieties (eg, driving, swimming, climbing, operating machinery).
• Clozaril may lift up your blood sugar. High blood sugar could make you're feeling confused, drowsy, or thirsty. It can also cause you to flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell your physician straight away.

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• Avoid food and drink full of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your doctor or dentist that you simply take Clozaril. It could have an effect on the medical or dental treatments, emergency care, or surgery you may receive.

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• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that may be brought on by Clozaril. Symptoms can include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact your physician simultaneously if you have any of these symptoms.

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• Some patients taking Clozaril may develop muscle movements that they cannot control. This is more prone to happen in elderly patients, especially women. The chance until this will happen or that it's going to become permanent is greater in those taking Clozaril in high doses and a long time. Muscle problems could also occur after short-term treatment with low doses. Tell your physician at once when you have muscle problems along with your tongue, face, mouth, jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.

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• Lab tests, including complete blood cell counts and heart function tests, could be performed to monitor your progress or search for negative effects. Be sure to keep all doctor and lab appointments.

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• Use Clozaril with caution within the elderly; they may be more responsive to its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.

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• Pregnancy and breast-feeding: If you conceive, contact your doctor. You will need to discuss the rewards and risks of using Clozaril while you happen to be pregnant. It is not known if Clozaril is located in breast milk. Do not breastfeed while taking Clozaril.

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