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• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) since the risk of their unwanted side effects could possibly be increased by Clozaril.

This may not be a complete report on all interactions that will occur. Ask your medical provider if Clozaril may communicate with other medicines that you just take. Check with your health care provider prior to starting, stop, or change the dose of any medicine.

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Important safety information:

• Clozaril could potentially cause drowsiness, dizziness, or lightheadedness. These effects might be worse if you go with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks unless you understand how you answer it.

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• Clozaril could potentially cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially inside the morning. Sit or lay down on the first manifestation of all of these effects.
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• Lab tests, including complete blood cell counts and heart function tests, might be performed to observe your progress or search for unwanted effects. Be sure to keep all doctor and lab appointments.
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