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Uses

INDICATIONS

Chloroquine is indicated to the suppressive treatment as well as for acute attacks of malaria on account of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the treatments for extraintestinal amebiasis.

INSTRUCTIONS

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Take chloroquine with meals or milk to minimize stomach upset, unless otherwise directed by your doctor.

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t is essential that you take chloroquine only as directed. Do not take really it, don't take on it more frequently, and don't take on it for a longer period than your doctor ordered. To do so could raise the chance of serious negative effects.

If you are taking chloroquine to hold you from getting malaria, keep taking it for the full-time of treatment. If you currently have malaria, you must still keep taking chloroquine for that fulltime of treatment even though you set out to feel good right after days. This will help to the infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine is best suited if you go on it on a regular schedule. For example, in case you are to take it once weekly to avoid malaria, it's always best to go on the same day per week. Or if you are to adopt two doses every day, one dose might be taken with breakfast as well as the other using the evening meal. Make sure that you just usually do not miss any doses. If you've questions concerning this, check with your wellbeing care professional.

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If you miss a dose of chloroquine, take it at the earliest opportunity. However, when it is almost time for your upcoming dose, skip the missed dose and return to your family dosing schedule. Do not double doses.

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DOSAGE 

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The dosage of chloroquine phosphate can often be expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the equal of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body mass.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on the identical day of per week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but must not exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy must start a fortnight ahead of exposure. However, failing this in older adults, a primary double (loading) dose of merely one g (= 600 mg base), or perhaps children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy ought to be continued for eight weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of merely one g (= 600 mg base) followed by yet another 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on every one of two consecutive days. This represents a complete dose of 2.5 g chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low body weight and for infants and children needs to be determined as follows:

First dose: 10 mg base per kg (and not exceeding one particular dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (and not exceeding just one dose of 300 mg base).

Third dose: (one day after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy by having an 8-aminoquinoline compound is necessary.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, as well as 500 mg (300 mg base) daily for around two to three weeks. Treatment is usually combined with an effective intestinal amebicide.

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STORAGE 

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Store the medicine in the closed container at room temperature, faraway from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of youngsters.

Do not keep outdated medicine or medicine no longer needed.

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Side Effects

Along having its needed effects, a medicine could potentially cause some negative effects. Although not most of these side effects may occur, when they do occur they will often need medical attention. When chloroquine can be used abbreviated durations, unwanted effects usually are rare. However, when it can be used for quite a long time and/or even in high doses, unwanted side effects are more inclined to occur and could be serious.

Check with your medical professional immediately if any of these unwanted effects occur:
Less common

Blurred vision
difference in vision
eye pain
loss of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or another mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any loss of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The unwanted side effects inside the Less Common category above might also occur or get worse as soon as you stop taking chloroquine.

Some negative effects may occur have a tendency to tend not to need medical assistance. These unwanted side effects may go away during treatment because your body adjusts for the medicine. Also, your wellbeing care professional may be able to tell you about ways to stop or reduce some of these side effects. Check with your health care professional if any of the following unwanted effects continue or are bothersome or if you have any queries about them:


More common

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Diarrhea
difficulty in seeing to read
headache
itching (more prevalent in black patients)
lack of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside mouth
skin rash

Other side effects unlisted may also appear in some patients. If you notice every other effects, talk with your doctor.

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Precautions

If you will be taking chloroquine for quite a long time, it is essential that your physician check you at regular visits for virtually any blood problems or muscle weakness that might be caused by chloroquine. In addition, check with your doctor immediately if blurred vision, difficulty in reading, or some other alternation in vision occurs during or after treatment. Your doctor may want you to have your vision checked by an ophthalmologist (eye doctor).

If your symptoms usually do not improve inside a few days or whenever they become worse, consult your medical professional.

Make sure you understand how you react to chloroquine prior to deciding to drive, use machines, or do anything else that might be dangerous in case you are not able to see well.

Chloroquine could potentially cause blurred vision, difficulty in reading, or any other alternation in vision. It could also cause some people for being lightheaded.

If these reactions are especially bothersome, check with your doctor.

Certain medicines must not be used at or around the time of eating or eating certain kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions that occurs. Discuss using your healthcare professional the usage of your medicine with food, alcohol, or tobacco.

There aren't any adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in women that are pregnant. Usage of chloroquine during pregnancy should be avoided except within the suppression or treatment of malaria when in the judgment in the physician the main benefit outweighs the possible risk towards the fetus.

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