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Promethazine is several drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals inside your brain. Promethazine also acts as a possible antihistamine. It blocks the results with the naturally occurring chemical histamine within your body.

Promethazine is used to take care of allergies such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Promethazine just isn't to be used for symptoms of asthma, pneumonia, or any other lower respiratory tract infections.

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Take promethazine exactly as prescribed because of your doctor. Do not take it in larger amounts or for over recommended. Follow the directions on your prescription label.

Your doctor may occasionally improve your dose to successfully obtain the best comes from prescription drugs.

Promethazine may be taken with or without food or milk.

Measure liquid medicine using a marked measuring spoon or medicine cup, not which has a regular table spoon. If you do not have a dose-measuring device, ask your friendly phamacist for just one.

Call a medical expert if the symptoms don't improve, or if they deteriorate while taking promethazine.

This medication might cause that you have unusual results with certain tests. Tell any doctor who treats you you are using promethazine.

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Seek emergency medical attention if you believe you might have used an excessive amount of this medicine. Overdose symptoms may include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.

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Take becoming prescribed by your doctor.


Store promethazine at room temperature far from moisture, heat, and light-weight.

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Side Effects

Get emergency medical help if you might have these warning signs of a hypersensitive reaction: hives; lack of breath; swelling of your face, lips, tongue, or throat. Stop using promethazine and call your doctor immediately if you might have some of these serious unwanted side effects:

twitching, or uncontrollable movements of the eyes, lips, tongue, face, arms, or legs;

tremor (uncontrolled shaking), drooling, trouble swallowing, difficulty with balance or walking;

feeling restless, jittery, or agitated;

high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;

feeling just like you might faint;

seizure (convulsions);

pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

hallucinations, agitation;

nausea and stomach pain, skin rash, and jaundice (yellowing in the skin or eyes);

urinating less than usual or otherwise in any way;

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy pores and skin; or

slow heartrate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious promethazine negative effects might include:

dizziness, drowsiness, anxiety;

blurred vision, dry mouth, stuffy nose;

ringing inside your ears;

weight gain, swelling with your hands or feet;

impotence, trouble having an orgasm; or


This just isn't a complete report on side effects yet others may occur. Tell a medical expert about any unusual or bothersome complication.


Stop using promethazine and call a medical expert at once if you've twitching or uncontrollable movements of your respective eyes, lips, tongue, face, arms, or legs. These could be early signs and symptoms of dangerous unwanted effects. Promethazine might cause unwanted effects that could impair your notions or reactions. Be careful in case you drive or do anything whatsoever that will need you to definitely be awake and alert. Avoid alcohol consumption, which can increase some in the negative effects of promethazine. There are many other medicines that could communicate with promethazine. Tell your medical professional about every one of the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and prescriptions given by other doctors. Do not use a new medication without telling your medical professional. Keep a list together with you of each of the medicines you utilize and show this list to any doctor and other doctor who treats you.

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Important safety information:

Promethazine really should not be given to a young child younger than a couple of years old. Promethazine can cause severe breathing problems or death in a youngster younger than 2. Carefully follow your physician's instructions when giving this medicine to a kid of any age. Do not use medicines if you might have severe asthma, emphysema, or another breathing problem, or in the event you are allergic to promethazine or any other phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you've got certain conditions, you might need a dose adjustment or special tests to soundly use medicines. Before you take promethazine, tell a medical expert if you've got:

a reputation seizures;

heart disease or hypertension;

liver or kidney disease;

severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or other breathing problem;

sleep apnea (breathing stops during sleep);


a stomach ulcer or digestive obstruction;

bone marrow depression;

adrenal gland tumor (pheochromocytoma);

enlarged prostate or difficulty with urination;

low numbers of calcium in your blood (hypocalcemia); or

if you might have ever a serious side effect while using the promethazine or any other phenothiazine.

FDA pregnancy category C. It is not known whether promethazine is harmful for an baby. Tell your medical professional in case you are pregnant or want to get pregnant during treatment. It is not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not use medicines without telling your doctor in the event you are breast-feeding a baby. Older adults could be more likely to have negative effects from promethazine.

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