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Uses

INDICATIONS

Indinavir can be an antiviral medication in the number of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within you. It is utilized to treat HIV, which in turn causes acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

INSTRUCTIONS

Take indinavir just as it was prescribed for you personally. Do not take the medication in larger amounts, or go on it for more than recommended by your doctor. Follow the directions on the prescription label.

This medication incorporates patient instructions for secure and efficient use. Follow these directions carefully. Ask a medical expert or pharmacist for those who have any questions.
Take indinavir which has a full glass (8 ounces) of water or skim milk. You may also drink juice, coffee, or tea with this particular medication. Drink no less than 6 servings of water on a daily basis to stop kidney stones if you are taking indinavir. Indinavir ought to be taken on a clear stomach, at the very least 60 minutes before or 120 minutes following a meal.

If you'd like to take the medication with food, eat only a light meal, such as dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is essential to make use of indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of medicine completely.

To be certain prescription drugs helps your complaint, your blood will need to be tested often. Your liver function may also need to be tested. Do not miss any scheduled visits to your medical professional.

HIV/AIDS is often treated having a combination of different drugs. To best treat your trouble, utilize all of your respective medications as directed because of your doctor. Be sure to see the medication guide or patient instructions provided with each of your respective medications. Do not make positive changes to doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain underneath the good care of a physician.

Take the missed dose as soon as you remember and take the following dose in the regularly scheduled time. If you are a lot more than 120 minutes late in taking your indinavir, skip the missed dose and make next regularly scheduled dose. Do not take extra medicine to generate in the missed dose.

DOSAGE

Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis should be initiated at the earliest opportunity, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is amongst the alternative regimens appropriate for nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy should start promptly, preferably within 1 to 2 hours postexposure. The exact use of therapy varies using the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider decreasing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is given concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence for the prescribed dose is essential. Patients must not alter the dose or discontinue therapy without conferring with their physician.

Adequate hydration (1.5 liters/day) is important during therapy to relieve the chance of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature far from moisture and also heat. Keep the capsules in their original container, with the packet of moisture-absorbing preservative that incorporates indinavir capsules.

Side Effects

Get emergency medical help when you have these signs of a hypersensitive reaction: hives; breathlessness; swelling of the face, lips, tongue, or throat. Stop taking indinavir and call your physician immediately when you have these serious side effects:

Less serious side effects may include:

This is not a complete listing of unwanted side effects while others may occur. Tell your physician about any unusual or bothersome side-effect.

Precautions

Do not take this medication in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines like ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs might cause life-threatening unwanted effects if you use them while you are taking indinavir.

Before taking indinavir, tell your physician should you be allergic to your drugs, or when you have:

If you might have some of these conditions, you may need a dose adjustment or special tests to soundly take indinavir.
FDA pregnancy category C. This medication could be bad for an child. Tell your medical professional in case you are pregnant or prefer to conceive during treatment. HIV might be passed towards the baby in the event the mother is just not properly treated during pregnancy. Take all of your respective HIV medicines as directed to moderate your infection if you are pregnant.

Your name may should be for auction on an antiviral pregnancy registry once you begin using prescription drugs.
You must not breast-feed while you're using indinavir. Women with HIV or AIDS should not breast-feed in any way. Even if your baby is born without HIV, you may still pass the herpes virus towards the baby with your breast milk.


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