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Precautions

Do NOT use Depakote if:

• you might be allergic to the ingredient in Depakote
• you might have liver problems or a urea cycle disorder.

Contact your medical professional or physician without delay if all of these apply to you.

Some health concerns may interact with Depakote. Tell your medical professional or pharmacist when you have any health concerns, especially if any of the following affect you:

• if you might be pregnant, likely to get pregnant, are breast-feeding
• should you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• when you have allergies to medicines, foods, or any other substances
• when you have a good irresponsible drinking, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood numbers of ammonia or glutamine, low body's temperature, low numbers of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation from the pancreas, kidney problems, or low degrees of white blood cells, or if you're scheduled for surgery
• for those who have a history of ornithine transcarbamylase deficiency or unexplained coma
• when you have a family good reputation for urea cycle disorders or unexplained infant deaths
• when you have a good mental or mood problems (eg, depression), or suicidal thoughts or actions
• if you're taking every other medicine for seizures.

Some medicines may interact with Depakote. Tell your health care provider in case you are taking any other medicines, especially any from the following:

• Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) as the probability of serious negative effects of Depakote, including adjustments to vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, could be increased
• Clonazepam since the probability of seizures could possibly be increased
• Topiramate as the likelihood of high ammonium levels, brain problems, or perhaps an unusual drop in temperature could possibly be increased
• Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control method pills), or rifampin simply because they may decrease Depakote's effectiveness
• Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the likelihood of their negative effects may be increased by Depakote.

This may not be a whole listing of all interactions which could occur. Ask your doctor if Depakote may talk with other medicines that you adopt. Check with your medical provider before you begin, stop, or affect the dose of the medicine.

Important safety information:

• Depakote could cause drowsiness, dizziness, or blurred vision. These effects might be worse in the event you take it with alcohol or certain medicines. Use Depakote with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depakote; it might add to their effects. Ask the pharmacist in case you have questions about which medicines could potentially cause drowsiness.
• Inflammation with the pancreas can be a potentially life-threatening illness linked to Depakote. Symptoms include stomach pain, vomiting, or decrease of appetite. Contact your physician immediately if all of these symptoms occur.
• Patients who take Depakote may be at increased risk for suicidal thoughts or actions. The risk might be greater in patients who may have had suicidal thoughts or actions in the past. Patients who have bipolar (manic-depressive) illness can also offer an increased risk for suicidal thoughts or actions. Watch patients taking Depakote closely. Contact a doctor immediately if new, worsened, or sudden symptoms, for example depressed mood; anxious, restless, irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact your physician without delay if any signs and symptoms of suicidal thoughts or actions occur.
• Depakote may reduce the quantity of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell a medical expert when you have unusual bruising or bleeding. Tell your medical professional in case you have dark, tarry, or bloody stools.
• Tell your medical professional or dentist that you adopt Depakote before you have any medical or dental treatments, emergency care, or surgery.
• Diabetes patients - Depakote might cause the outcomes of some tests for urine ketones to become wrong. Ask your physician before you decide to change your diet or perhaps the dose of the diabetes medicine.
• Depakote might increase the ammonia levels in your blood. Contact your physician immediately in case you experience unexplained sluggishness and vomiting or mental changes.
• Depakote might cause a rare drop in body's temperature (hypothermia). Symptoms can sometimes include confusion, deficiency of energy, decrease of coordination, shivering, slow heartbeat, slow or shallow breathing, slurred speech, or unusual drowsiness. Contact your medical professional immediately in case you have all of these symptoms.
• Depakote may restrict certain tests, including thyroid function. Be sure your physician and lab personnel know you take Depakote
• Lab tests, including complete blood cell counts, blood ammonia levels, and liver function, could possibly be performed whilst you use Depakote. These tests might be used to monitor your trouble or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Depakote with caution inside elderly; they could be more understanding of its effects, especially drowsiness.
• Depakote needs to be used in combination with careful attention in children younger than decade old; safety and effectiveness in these children haven't been confirmed. Children younger a couple of years could possibly be at increased probability of serious liver problems.
• Pregnancy and breast-feeding: Depakote is shown to harm the fetus. Use an effective form of birth control method while you take Depakote. If you think you might be pregnant or if you wish to become pregnant, contact your medical professional. You will need to discuss the huge benefits and perils associated with using Depakote when you are pregnant. Depakote is found in breast milk. Do not breastfeed while you're taking Depakote.