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ARAVA is indicated in adults to the treatments for active arthritis rheumatoid (RA):


Take this medicine only as directed from your doctor. Do not take really it, don't take on it more regularly, and don't take on it much more time than your physician ordered.

The dose of the medicine changes for various patients. Follow your medical professional's orders or even the directions on the label. The following information includes merely the average doses with this medicine. If your dose is unique, tend not to put it back unless a medical expert notifys you to take action.

The volume of medicine which you take depends for the strength from the medicine. Also, the volume of doses you are taking each day, time allowed between doses, and the time period you are taking the medicine depend around the disease you simply are choosing the medicine.

For oral dosage form (tablets):

For rheumatism:

If you miss a dose with this medicine, take it immediately. However, when it is almost time for your upcoming dose, skip the missed dose and get back on your normal dosing schedule. Do not double doses.


Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out with the reach of youngsters. Do not keep outdated medicine or medicine don't needed. Store the medicine in a very closed container at room temperature, away from heat, moisture.

 Keep out with the reach of youngsters. Do not keep outdated medicine or medicine don't needed. Store the medicine in a very closed container at room temperature, away from heat, moisture.


Side Effects

Stop applying this medicine and check with your doctor immediately if you're having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be signs of a condition called peripheral neuropathy.

Adverse reactions associated with the usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along having its needed effects, medication might cause some uncomfortable side effects. Although not all of these side effects may occur, should they do occur they could need medical help.

Check with a medical expert immediately if any of the following negative effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
lack of appetite
sore throat
tightness within the chest
yellow eyes or skin
Less common
Burning feeling in the chest or stomach
burning, prickling, or tingling sensation within the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
tenderness inside stomach area
unusual tiredness or weakness
Incidence not known
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
lower back or side pain
pains inside the stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots on the skin
rapid, shallow breathing
red lesions on the skin, often which has a purple center
red, irritated eyes
sores, ulcers, or white spots inside the mouth or about the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness within the arms, hands, legs, or feet

Some side effects may occur that usually tend not to need medical help. These unwanted side effects might have to go away during treatment since your body adjusts towards the medicine. Also, your wellbeing care professional may be able to share with you ways to prevent or reduce some of these unwanted side effects. Check along with your health care professional if any of the following negative effects continue or are bothersome or if you might have any questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness from the mouth
itching from the skin
pain or burning inside the throat
runny nose

Other unwanted effects not listed can also occur in some patients. If you notice some other effects, check along with your healthcare professional.



It is very important that your doctor check your progress at regular visits to make certain that this medicine is working properly. Blood tests may be needed to check on for unwanted effects.

Using this medicine while you're pregnant can harm your unborn baby. Use an effective way of contraceptive to keep from having a baby. If you think you have get pregnant with all the medicine, tell your physician right away.

Leflunomide may also cause birth defects if your father is applying it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms like a way of contraception during sexual activity. A man aiming to father a child should stop using this medicine and look with his doctor immediately.

Serious skin reactions can occur using this type of medicine. Stop employing this medicine and appearance with your doctor straight away if you've got any with the following symptoms while using this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red skin lesions, often with a purple center; sores, ulcers, or white spots inside the mouth or for the lips; or unusual tiredness or weakness.

Liver problems may occur while you are employing this medicine. Stop applying this medicine and look with your doctor right away if you are having more than one of such symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; loss of appetite; feeling sick; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the volume of white blood cells within your blood, enhancing the probability of getting infection. It can also lower the number of platelets, which are essential for proper blood clotting. If this occurs, there are particular precautions you can take, specially when your blood count is low, to lessen potential risk of infection or bleeding:

Check with your physician without delay if you've a cough with or without temperature, shortness of breath, or any issue with breathing.

You should have a skin test for tuberculosis before you start applying this medicine. Tell your doctor in case you or anyone in your home has ever endured an optimistic a reaction to a tuberculosis test.

Using this medicine may enhance your likelihood of getting serious infections or cancer. Talk to your doctor if you've concerns about this risk.

Do not take other medicines unless they've been discussed with your physician. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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