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Uses

INDICATIONS

Chloroquine is indicated to the suppressive treatment and for acute attacks of malaria because of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for your treating extraintestinal amebiasis.

INSTRUCTIONS

Take chloroquine with meals or milk to cut back stomach upset, unless otherwise directed by your doctor.

t is critical that you take chloroquine only as directed. Do not take a greater portion of it, do not take on it more frequently, and do not take on it for a longer time than your medical professional ordered. To do so may increase the potential for serious side effects.

If you're taking chloroquine to keep you from getting malaria, keep taking it for that fulltime of treatment. If you already have malaria, you need to still keep taking chloroquine for the full-time of treatment in case you start to feel good after a couple of days. This will help to clear the infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine is most effective when you go on it with a regular schedule. For example, if you are to go on it once per week to avoid malaria, it is advisable to go on it on the same day per week. Or in case you are to look at two doses every day, one dose may be taken with breakfast as well as the other with the evening meal. Make sure which you don't miss any doses. If you've questions relating to this, check with your health care professional.

If you miss a dose of chloroquine, go as quickly as possible. However, when it is almost time for your next dose, skip the missed dose and return to your family dosing schedule. Do not double doses.

DOSAGE 

The dosage of chloroquine phosphate is usually expressed when it comes to equivalent chloroquine base. Each 500 mg tablet of ARALEN provides the equal of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on the identical day of weekly.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body mass, but ought not exceed the adult dose irrespective of weight.

If circumstances permit, suppressive therapy has to start a fortnight prior to exposure. However, failing this in adults, a preliminary double (loading) dose of a single g (= 600 mg base), or in children 10 mg base/kg could be used two divided doses, six hours apart. The suppressive therapy must be continued for 8 weeks after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of a single g (= 600 mg base) as well as yet another 500 mg (= 300 mg base) after six to eight hours along with a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents an overall dose of 2.5 g chloroquine phosphate or 1.5 g base in 72 hours.

The dosage for adults of low bodyweight and then for infants and children should be determined as follows:

First dose: 10 mg base per kg (although not exceeding one particular dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (and not exceeding a single dose of 300 mg base).

Third dose: (twenty four hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with the 8-aminoquinoline compound is essential.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, accompanied by 500 mg (300 mg base) daily for at least two to three weeks. Treatment is usually combined with the effective intestinal amebicide.

STORAGE 

Store the medicine in the closed container at room temperature, from heat, moisture, and direct light. Keep from freezing.

Keep out of your reach of children.

Do not keep outdated medicine or medicine don't needed.

Side Effects

Along featuring its needed effects, medication may cause some unwanted effects. Although not many of these negative effects may occur, if they occur they could need medical attention. When chloroquine is used in short durations, unwanted side effects tend to be rare. However, when it is used for quite a long time and/or even in high doses, unwanted side effects may occur and may be serious.

Check with a medical expert immediately if any of these unwanted effects occur:
Less common

Blurred vision
alternation in vision
eye pain
decrease of vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood and other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any lack of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The unwanted side effects in the Less Common category above could also occur or become worse as soon as you stop taking chloroquine.

Some unwanted side effects may occur have a tendency to usually do not need medical assistance. These side effects might go away during treatment as the body adjusts for the medicine. Also, your wellbeing care professional could be able to share with you ways to avoid or reduce many of these side effects. Check with your health care professional if these things unwanted effects continue or are bothersome or if you have any queries about them:


More common


Diarrhea
difficulty in seeing to read
headache
itching (more established in black patients)
decrease of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or in mouth
skin rash

Other unwanted side effects unpublished could also appear in some patients. If you notice every other effects, talk with your health care professional.

Precautions

If you may be taking chloroquine for a very long time, it is vital that your medical professional check you at regular visits for almost any blood problems or muscle weakness that could be brought on by chloroquine. In addition, talk with your medical professional immediately if blurred vision, difficulty in reading, or every other difference in vision occurs during or after treatment. Your doctor might prefer one to have the eyes checked by an ophthalmologist (eye doctor).

If your symptoms don't improve in a couple of days or whenever they become worse, consult a medical expert.

Make sure you are aware how you react to chloroquine when you drive, use machines, or do just about anything else that might be dangerous if you are not able to see well.

Chloroquine may cause blurred vision, difficulty in reading, or another difference in vision. It may also cause many people being lightheaded.

If these reactions are specially bothersome, consult your medical professional.

Certain medicines should not be used at or around the time of eating food or eating some kinds of food since interactions may occur. Using alcohol or tobacco with certain medicines can also cause interactions to take place. Discuss along with your doctor the use of your medicine with food, alcohol, or tobacco.

There aren't adequate and well-controlled studies evaluating the protection and efficacy of chloroquine in women that are pregnant. Usage of chloroquine during pregnancy should be avoided except inside the suppression or treatment of malaria when in the judgment in the physician the main benefit outweighs the opportunity risk towards the fetus.


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