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Precautions

Do NOT use Clozaril if:

• you happen to be allergic to your ingredient in Clozaril
• you have bone marrow problems, other blood cell problems, or a good reputation for blood problems caused by Clozaril
• you've got uncontrolled seizures (eg, epilepsy) or lack of bowel muscle movement (paralytic ileus)
• you've severe drowsiness
• you consider other medicines that may cause blood problems. Ask your physician in case you are unsure if any medicines could potentially cause blood problems.

Contact your physician or doctor right away if these sign up for you.

Some medical conditions may talk with Clozaril. Tell a medical expert or pharmacist if you have any medical ailments, particularly if any of the following connect with you:

• should you be pregnant, planning to get pregnant, or are breast-feeding
• if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• in case you have allergies to medicines, foods, and other substances
• for those who have a history of blood clots, blood problems, high blood cholesterol, heart disease, or lung or breathing problems
• for those who have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia
• for those who have poor health, diabetes, or a member of the family with diabetes, or you happen to be very overweight
• if you have decreased activity of enzymes that metabolize certain medicines.

Some medicines may talk with Clozaril. Tell your medical provider if you take another medicines, especially any from the following:

• Benzodiazepines (eg, lorazepam) or any other medicines for mental or mood problems as the probability of heart or breathing problems could possibly be increased
• Cimetidine, erythromycin, quinolone antibiotics (eg, ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) given that they may increase the likelihood of Clozaril's side effects
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nicotine, or rifampin given that they may decrease Clozaril's effectiveness
• Antiarrhythmics (eg, propafenone, quinidine), anticholinergics (eg, benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (eg, chlorpromazine), or tricyclic antidepressants (eg, amitriptyline) since the risk of their unwanted effects might be increased by Clozaril.

This is probably not a total set of all interactions that will occur. Ask your doctor if Clozaril may interact with other medicines which you take. Check together with your doctor before starting, stop, or affect the dose from a medicine.

Important safety information:

• Clozaril could potentially cause drowsiness, dizziness, or lightheadedness. These effects could be worse if you take it with alcohol or certain medicines. Use Clozaril with caution. Do not drive or perform other possible unsafe tasks until you know how you respond to it.
• Do not use alcohol or medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) as you taking Clozaril. It may increase their effects. Ask your pharmacist if you have questions regarding which medicines may cause drowsiness.
• Clozaril could cause dizziness, lightheadedness, or fainting; alcohol, summer, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially in the morning. Sit or lie down with the first sign of some of these effects.
• Clozaril may lower the ability of one's body to fight infection. Avoid connection with those who have colds or infections. Tell your medical professional straight away you may notice any warning signs of infection like fever, sore throat, rash, chills, mouth or nose sores, or unusual tiredness or weakness.
• Women and patients of Jewish background may be at greater probability of developing blood difficulty with Clozaril.
• If you've a history of seizures, you might suddenly lose conscious whilst you consider Clozaril. Avoid activities where decrease of conscious could be dangerous for your requirements or others (eg, driving, swimming, climbing, operating machinery).
• Clozaril may raise your blood sugar. High blood glucose levels could make you're feeling confused, drowsy, or thirsty. It can also cause you to flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell your doctor immediately.
• Avoid drink and food an excellent source of caffeine, like coffee, tea, cocoa, cola, and chocolate.
• Tell your medical professional or dentist that you take Clozaril. It could influence the medical or dental hygiene, emergency care, or surgery you could possibly receive.
• Neuroleptic malignant syndrome (NMS) is often a possibly fatal syndrome which can be due to Clozaril. Symptoms can include fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. Contact a medical expert at once for those who have any of these symptoms.
• Some patients having Clozaril may develop muscle movements that they cannot control. This is more likely to occur in elderly patients, especially women. The chance this may happen or that it will become permanent is greater in those having Clozaril in high doses or for a very long time. Muscle problems might also occur after short-term treatment with low doses. Tell your doctor at the same time if you have muscle problems using your tongue, face, mouth, jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements), arms, or legs while taking Clozaril.
• Lab tests, including complete blood cell counts and heart function tests, may be performed to observe your progress or search for negative effects. Be sure to keep all doctor and lab appointments.
• Use Clozaril with caution in the elderly; they could possibly be more understanding of its effects, especially blood problems, dizziness (especially upon standing), fast heartbeat, urinary problems, and constipation.
• Clozaril ought to be combined with extreme caution in kids; safety and effectiveness in children weren't determined.
• Pregnancy and breast-feeding: If you conceive, contact your doctor. You will need to discuss the benefits and perils associated with using Clozaril while you happen to be pregnant. It is not known if Clozaril can be found in breast milk. Do not breastfeed while taking Clozaril.