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Prandin (repaglinide) is an oral diabetes medicine which enables control blood glucose levels. This medication lowers blood glucose by creating the pancreas to create insulin.

Prandin is utilized together with dieting and exercise to help remedy diabetes. Other diabetes medicines are sometimes employed in in conjunction with repaglinide as needed.

Prandin may aso be used for purposes unlisted on this medication guide.


Take Prandin the same manner prescribed by your doctor. Do not take in larger or smaller amounts and for more than recommended. Follow the directions on your own prescription label.

Prandin is generally taken 2 to 4 times daily, within a half-hour before eating meals. Follow your doctor's instructions. If you skip a meal, don't take on your dose of Prandin. Wait until the next meal.

Your blood glucose will have to be checked often, and you might need other blood tests at the doctor's office. Visit your medical professional regularly.

Know signs and symptoms of low blood glucose levels (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a method to obtain sugar obtainable in case you've symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you've severe hypoglycemia and can't eat or drink, work with an injection of glucagon. Your doctor can provide you with a prescription for a glucagon emergency injection kit and tell you the best way to provide the injection.

Also watch for signs and symptoms of blood glucose levels which is excessive (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight-loss.

Check your blood sugar carefully during a duration of stress or illness, in case you travel, exercise more than usual, are drinking alcoholic beverages, or skip meals. These things can impact your glucose levels along with your dose needs could also change.

Your doctor may want one to stop taking Prandin to get a limited time in the event you get sick, use a fever or infection, or if you've got surgery or a medical emergency.

Ask your physician how to adjust your Prandin dose as needed. Do not improve your medication dose or schedule without a medical expert's advice.

Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight management. Follow your diet, medication, and workout routines very closely. Changing all of these factors can impact your blood sugar levels.

Use Prandin regularly to get the most benefit. Get your prescription refilled before you run out of medication completely.





Active ingredient: Repaglinide

Repaglinide can be a white to off-white powder with molecular formula C27 H36 N2 O4 as well as a molecular weight of 452.6. PRANDIN tablets contain 0.5 mg, 1 mg, or 2 mg of repaglinide. In addition each tablet provides the following inactive ingredients: calcium hydrogen phosphate (anhydrous), microcrystalline cellulose, maize starch, polacrilin potassium, povidone, glycerol (85%), magnesium stearate, meglumine, and poloxamer. The 1 mg and two mg tablets contain iron oxides (yellow and red, respectively) as coloring agents.



Side Effects

Weight gain, diarrhea, and joint may occur. If these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed medicines while he or she's judged that this profit to you is greater than the potential risk of side effects. Many people using this medication will not have serious side effects.

Repaglinide can cause low blood glucose levels (hypoglycemia) especially if you take other medicines for diabetes. Consuming bulk of alcohol, to not get enough calories from food, or doing unusually heavy exercise could also result in low blood sugar levels. Symptoms might include chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling from the hands or feet, or hunger. It is really a good habit to hold glucose tablets or gel to help remedy low blood glucose. If you don't have these reliable forms of glucose, increase your blood sugar quickly to eat a simple way to obtain sugar for example table sugar, honey, candy, or drinking a glass of liquid or non-diet soda. Check with a medical expert or pharmacist to learn what you should do should you miss dinner.

Symptoms of high blood glucose (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your medical professional immediately. Your doctor might need to adjust your diabetes medication(s).

A serious allergic reaction to this particular drug is rare. However, seek immediate medical attention in the event you notice any from the following signs of a serious allergic reaction: rash, itching/swelling (especially from the face/tongue/throat), severe dizziness, trouble breathing.

This is not a total set of possible unwanted effects. If you notice other effects not listed above, contact a medical expert or pharmacist.


More info:

Tell your doctor about all other medications you use, especially:

cyclosporine (Gengraf, Neoral, Sandimmune);

St. John's wort;

an antibiotic like clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

an antifungal medication including fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);

a barbiturate such as phenobarbital (Solfoton);

heart or blood pressure levels medication such as diltiazem (Cartia, Cardizem), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), yet others;

HIV/AIDS medicine like delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir), among others;

rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin); or

seizure medication for example carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), primidone (Mysoline), among others.

You might be more prone to have hyperglycemia (high blood glucose levels) in the event you take Prandin with other drugs that raise blood glucose levels, like:


diuretics (water pills);

steroids (prednisone yet others);

phenothiazines (Compazine while others);

thyroid medicine (Synthroid yet others);

birth control pills as well as other hormones;

seizure medicines (Dilantin among others); and

diet pills or medicines to deal with asthma, colds or allergies.

You might be more likely to have hypoglycemia (low blood glucose levels) in the event you take other drugs that lower blood glucose, like:

probenecid (Benemid);

a blood thinner (warfarin, Coumadin);

some nonsteroidal anti-inflammatory drugs (NSAIDs);

aspirin or another salicylates (including Pepto-Bismol);

a blood thinner (warfarin, Coumadin, Jantoven, while others);

sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);

a monoamine oxidase inhibitor (MAOI); or

other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos, Duetact, Actoplus Met), or rosiglitazone (Avandia, Avandaryl, Avandamet).

These lists usually are not complete and there are lots of other medicines that could increase or decrease the effects of Prandin on cutting your blood glucose levels. Using certain medicines makes it harder for one to tell when you've low blood glucose. Tell your physician about all medications you utilize. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your medical professional.


Do not use Prandin if you are allergic to repaglinide, if you might have type 1 diabetes, or in the event you are in a state of diabetic ketoacidosis (call your physician for treatment with insulin). You should not use Prandin as well as gemfibrozil (Lopid) or NPH insulin (for example isophane insulin).

Before taking repaglinide, tell a medical expert or pharmacist in the event you are allergic to it; or if you have some other allergies. This product may contain inactive ingredients, which may cause hypersensitive reactions or another problems. Talk to your pharmacist for additional information. 

Before using medicines, tell a medical expert or pharmacist your track record, especially of: kidney disease, liver disease.

You may feel blurred vision, dizziness, or drowsiness as a result of extremely low or high blood sugar levels. Do not drive, use machinery, or go activity that will need alertness or clear vision and soon you are sure you can perform such activities safely.

Limit alcohol while taking medicines given it can increase the risk of developing low blood glucose.

During points during the stress, for example fever, infection, injury, or surgery, it could be more challenging to manage your blood sugar. Consult a medical expert because increased stress might require a modification of your plan for treatment, medications, or blood sugar testing.

During pregnancy prescription drugs should supply only when clearly needed. Pregnancy could potentially cause or worsen diabetes. Discuss a strategy with your doctor for managing your blood sugar while pregnant. Your doctor may make positive changes to diabetes treatment during your pregnancy. Discuss the risks and great things about different treatments (for example diet, exercise, and medications including insulin).

FDA pregnancy category C. It is not known whether Prandin will harm an baby. Tell your doctor if you are pregnant or plan to conceive while using the Prandin. It is not known whether repaglinide passes into breast milk or if it can be harmful to a nursing baby. You should not breast-feed while you are taking Prandin.

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