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Precautions

Do NOT use Duetact if:

• you are allergic to any ingredient in Duetact
• you've moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems associated with diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or high blood acid levels (acidosis)
• you might have type 1 diabetes
• you are taking bosentan.

Contact your physician or physician right away if these apply to you.

Some medical conditions may interact with Duetact. Tell your medical professional or pharmacist when you have any medical ailments, in particular when any with the following affect you:

• if you're pregnant, likely to become pregnant, or are breast-feeding
• if you consider any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or another substances
• when you have had an intense allergic attack (eg, severe rash, hives, breathing difficulties, dizziness) to any other sulfonamide medicine including acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• in case you have a good kidney, thyroid, heart, or circulatory problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or 'abnormal' amounts of your enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• if you have stomach or irregularity (eg, stomach or bowel blockage, stomach paralysis), drink alcohol, or also have poor nutrition
• if you have inadequate health, a top fever, a serious infection, severe diarrhea, high blood acid levels, or brain or nervous system problems, or also have a serious injury
• for those who have a history of bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• in case you have swelling problems (edema) or certain eye problems (macular edema)
• if you'll be having surgery.

Some medicines may talk with Duetact. Tell your health care provider in the event you are taking any other medicines, especially any from the following:

• Bosentan because liver problems may occur, and the effectiveness of both medicines may be decreased
• Beta-blockers (eg, propranolol) as the probability of low blood sugar levels could be increased. They may also hide certain warning signs of low blood glucose making it harder to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) for the reason that likelihood of low blood glucose levels could be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control method pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) because they may decrease Duetact's effectiveness, causing high blood sugar
• Gemfibrozil because blood glucose levels could be increased or decreased
• Anticoagulants (eg, warfarin) as their effectiveness might be decreased or perhaps the chance of their side effects may be increased by Duetact.

This might not be a total set of all interactions which could occur. Ask your health care provider if Duetact may communicate with other medicines that you just take. Check with your medical provider before you start, stop, or affect the dose of the medicine.

Important safety information:

• Duetact could potentially cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects could possibly be worse in the event you go on it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you respond to it.
• Do not are drinking alcoholic beverages as you are taking Duetact; it may raise the likelihood of low blood glucose. Rarely, alcohol may connect to Duetact and result in a serious reaction with symptoms including flushing, nausea, vomiting, dizziness, or stomach pain. Discuss questions or concerns along with your doctor.
• Carry an ID card all the time that says you've got diabetes.
• Proper diet and exercise are important in order to lose fat and make them back. Follow the diet and exercise program presented to you from your doctor.
• Check your blood sugar levels as directed from your doctor. If they are often higher or below they must be and you take Duetact the same manner prescribed, tell your medical professional.
• It could be harder to control your blood glucose levels during periods of stress such as fever, infection, injury, or surgery. Talk together with your doctor about how exactly to control your blood glucose levels if some of these occur. Do not alter the dose of your medicine without checking together with your doctor.
• Do not take greater than the recommended dose without checking with your doctor.
• Duetact could cause low blood sugar levels levels. Low blood glucose could make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also help make your heart beat faster; you could make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is really a good plan to transport a dependable supply of glucose (eg, tablets or gel) to treat low blood glucose levels. If this is not available, you must eat or drink a quick method to obtain sugar like ordinary sugar, honey, candy, orange juice, or non-diet soda. This will increase your blood sugar levels level quickly. Tell your physician right away if this happens. To prevent low blood glucose levels, eat meals as well daily and never skip meals.
• Risk of low blood glucose could possibly be increased by severe or prolonged exercise, having a drink, or skipping meals.
• Duetact contains a sulfonylurea. It may improve the risk of death from heart disease. Talk together with your doctor regarding the benefits and perils associated with this or any other therapies to deal with your complaint.
• Duetact may cause ovulation ladies that have not reached menopause but don't ovulate. To avoid pregnancy, be sure to work with effective birth control while using Duetact.
• Duetact may cause you to become sunburned quicker. Avoid the sun, sunlamps, or tanning booths until you understand how you react to Duetact. Use a sunscreen or wear protective clothing in the event you have to be outside for over a small amount of time.
• Tell your medical professional or dentist which you take Duetact prior to deciding to get any medical or dental care, emergency care, or surgery.
• Duetact could be related to an increased risk of bladder cancer. Discuss any queries or concerns along with your doctor.
• An increased incidence of bone fracture has been reported in ladies taking Duetact. Tell your doctor for those who have a good reputation for bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell a medical expert right away if you experience any unusual bone pain.
• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, might be performed as you use Duetact. These tests may be used to monitor your complaint or search for unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution inside elderly; they could possibly be more responsive to its effects, specially the chance of heart problems or low blood sugar.
• Duetact mustn't be used in children; safety and effectiveness in children weren't confirmed.
• Pregnancy and breast-feeding: Duetact may cause problems for the fetus or newborn. If you think you could be pregnant, contact your doctor. You will need to discuss the huge benefits and risks of using Duetact while you are pregnant. It is not known if Duetact is located in breast milk. Do not breastfeed while taking Duetact.

When used for a long time Duetact may well not are well. If your blood glucose levels continues to be in check then becomes hard to manage, get hold of your doctor. Do not change the dose of the medicine without checking using your doctor.