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Micronase (Glyburide) is an oral diabetes medicine that assists control glucose levels.

Glyburide is used to take care of diabetes type 2.

This medication is not for treating type 1 diabetes.

Glyburide could also be used for other purposes unpublished within this medication guide.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts and for longer than recommended. Follow the directions in your prescription label. Your doctor may occasionally improve your dose to ensure that you acquire the best results.

Take glyburide with your first meal during the day, unless your doctor notifys you otherwise.

Your blood glucose levels will have to be checked often, and you'll need other blood tests at your physician's office. Visit your medical professional regularly.
Know the signs and symptoms of low blood glucose (hypoglycemia) and ways to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.

Always keep a source of sugar obtainable in case you have signs and symptoms of low blood glucose. Sugar sources include orange juice, glucose gel, candy, or milk. If you might have severe hypoglycemia and cannot eat or drink, make use of an injection of glucagon. Your doctor can provide you with a prescription to get a glucagon emergency injection kit and inform you the best way to supply the injection.

Also watch for warning signs of blood glucose that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dried-out skin, blurred vision, and weight loss.

Check your blood glucose levels carefully after a time of stress or illness, in case you travel, exercise more than usual, are drinking alcohol, or skip meals. These things can affect your sugar levels plus your dose needs can also change.

Your doctor might want one to stop taking glyburide for a limited time if you become ill, have a very fever or infection, or if you have surgery or a medical emergency.
Ask your physician how you can adjust your glyburide dose if needed. Do not make positive changes to medication dose or schedule without your physician's advice.

If you will find any adjustments to the brand, strength, or kind of glyburide you have, your dosage needs may change. Always check your refills to successfully have received the best brand and form of medicine prescribed from your doctor.


Take as prescribed from your doctor.


Store at room temperature, shielded from moisture, heat, and lightweight.


Active ingredient: Glyburide

Side Effects

Stop using glyburide and get emergency medical help if you have any of these indications of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat. Stop taking this medication and call a medical expert simultaneously if you have these serious unwanted side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes);

pale skin, confusion or weakness;

easy bruising or bleeding, purple or red pinpoint spots under your skin; or

headache, trouble concentrating, memory problems, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious unwanted side effects can include:

mild nausea, heartburn, feeling full;

joint or muscle pain;

blurred vision; or

mild itching or skin rash.

This is not a complete report on side effects among others may occur. Call a medical expert for health advice about unwanted effects.


You must avoid using prescription drugs should you are allergic to glyburide, or:

in case you are being treated with bosentan (Tracleer);

if you have type 1 diabetes; or

should you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To be sure you can safely take glyburide, tell a medical expert if you've got all of these other conditions:

hemolytic anemia (an absence of red blood cells);

an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

a nerve disorder affecting bodily functions;

liver or kidney disease;

in case you are allergic to sulfa drugs; or

if you might have been using insulin or taking chlorpropamide (Diabinese).

Certain oral diabetes medications may increase your chance of serious heart disease. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor concerning the risks and advantages of treating your diabetes with glyburide.

FDA pregnancy category C. It is not known whether glyburide will harm an baby. Similar diabetes medications have caused severe hypoglycemia in newborns whose mothers had used the medication at the duration of delivery. Tell a medical expert should you are pregnant or intend to conceive with all the medicines. It is not known whether glyburide passes into breast milk or if it could possibly harm a nursing baby.

Do not use medicines without telling a medical expert in case you are breast-feeding a baby. Older adults could possibly be very likely to have low blood glucose levels while taking glyburide.


Important safety information:

You should avoid using medicines in case you are allergic to glyburide, in case you are receiving treatment with bosentan (Tracleer), if you might have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glyburide, tell your physician in the event you are allergic to sulfa drugs, if you've got been using insulin or chlorpropamide (Diabinese), or if you've got hemolytic anemia (too little red blood cells), an enzyme deficiency (G6PD), a nerve disorder, liver disease, or kidney disease.

Take care not to let your blood glucose get too low. Low blood sugar (hypoglycemia) can happen if you skip meals, exercise to much time, are drinking alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you've got low blood glucose. Other sugar sources include orange juice and milk. Be sure your family and good friends know how to assist you in an urgent situation.

Drug interactions

Tell your medical professional about all the medications you use, especially:

a blood thinner for example warfarin (Coumadin, Jantoven);

cyclosporine (Gengraf, Neoral, Sandimmune);

disopyramide (Norpace);

fluconazole (Diflucan), ketoconazole (Nizoral);

fluoxetine (Prozac);

rifampin (Rifadin, Rimactane, Rifater);

an ACE inhibitor such as enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), while others; or

an antibiotic like ciprofloxacin (Cipro), levofloxacin (Levaquin), and others.

Using certain medicines will make it harder for you to tell when you've got low blood glucose. Tell a medical expert in the event you use these things:

albuterol (Proventil, Ventolin);

clonidine (Catapres);

reserpine; or

beta-blockers like atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), while others.

You could be very likely to have hyperglycemia (high blood glucose) in the event you take glyburide with:


diuretics (water pills);

steroids (prednisone and others);

phenothiazines (Compazine yet others);

thyroid medicine (Synthroid while others);

birth control pills and also other hormones;

heart or blood pressure medications (Cartia, Cardizem, Nifedical, Covera, Verelan, while others);

niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, yet others);

seizure medicines (Dilantin among others); and

diet pills or medicines to help remedy asthma, colds or allergies.

You could be more prone to have hypoglycemia (low blood glucose levels) in case you take glyburide with:

clarithromycin (Biaxin);

exenatide (Byetta);

probenecid (Benemid);

heart or blood pressure levels medication (Accupril, Altace, Lotensin, Prinivil, Vasotec, Zestril, yet others);

some nonsteroidal anti-inflammatory drugs (NSAIDs);

aspirin or any other salicylates (including Pepto-Bismol);

sulfa drugs (Bactrim, Gantanol, Septra, yet others);

a monoamine oxidase inhibitor (MAOI); and

other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

These lists are not complete and you can find many other medicines that can increase or minimizing the effects of glyburide on reducing your blood sugar levels. Tell your physician about all medications you utilize. This includes prescription, over-the-counter, vitamin, and herbal products. Do not begin a new medication without telling your doctor.


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